Cholinergic drugs | Parasympathomimetics classification and mechanism of...

Cholinergic drugs - 01 | Parasympathomimetics classification and mechanism of action - Pharmacology This video is all about Cholinomimetics also known as Cholinergic agonists, Parasympathomimetics, parasympathetic agonists, cholinergic receptor agonists. these are the agents which mimic or produce action like that of parasympathetic nervous system stimulation and that's why called parasympathomimetics. they are named cholinomimetics, as these agents show action like that of acetylcholine. acetylcholine is an acetylated choline molecule that normally functions as a neurotransmitter in our body. cholinergic drugs are classified as direct-acting drugs and indirect-acting drugs. direct-acting drugs or agonists bind directly to cholinergic receptors such as muscarinic receptors and nicotinic receptors, show their actions. while the indirect-acting agonists bind to and inhibit the action of the acetylcholinesterase enzyme. acetylcholinesterase is an enzyme present in the synaptic cleft that metabolizes acetylcholine and terminates its action. by inhibiting this enzyme the acetylcholine concentration rises in the synaptic cleft and thus activates all cholinoceptors that is muscarinic receptors and nicotinic cholinoceptors.

the direct-acting agonists are further classified as muscarinic agonists, nicotinic agonists, and mixed agonists. the muscarinic agonists specifically bind to muscarinic receptors and show their actions, while the nicotinic agonists bind to nicotinic receptors only and show their action, in contrast, the mixed agonists bind to both cholinoceptors and show their effects. the indirect-acting agonists are further classified on the basis of the interaction between the enzyme and the cholinergic agonists. and these are classified as reversible indirect-acting agonists and irreversible indirect-acting agonists. the reversible agents bind to the enzyme for a short period of time and leave the enzyme functional again, while the irreversible acting agents form a strong covalent bond with the enzyme which is not reversible. COVERED TOPICS PARASYMPATHOMIMETICS also known as cholinomimetics, cholinergic agonists, cholinergic receptors agonists, acetylcholine receptors agonists, parasympathetic drugs, parasympathetic agonists. 1. parasympathomimetics classification 1.1. direct-acting agonists 1.1.1. muscarinic agonists 1.1.2. nicotinic agonists 1.1.3. Mixed agonists 1.2. Indirect acting agonists 1.2.1. Reversible acting agonists 1.2.2. Irreversible acting agonists 2. Mechanism of action of parasympathomimetics or cholinergic drugs 2.1. Mechanism of action of muscarinic agonists 2.2. Mechanism of action of nicotinic agonists 2.3. Mechanism of action of mixed agonists 2.4. Mechanism of action of reversible agonists 2.5. Mechanism of action of irreversible agonists LINKS: Also, watch Cholinergic transmission | acetylcholine synthesis & metabolism | cholinergic drugs | pharmacology https://youtu.be/PBsCl95X3DI Cholinergic receptors | Muscarinic and Nicotinic receptors - Pharmacology https://youtu.be/uQ4ILypFKog sympathetic vs parasympathetic nervous system | Autonomic nervous system - Pharmacology https://youtu.be/U7qbF42G6kA Sympathetic nervous system | Autonomic nervous system | Nervous system - pharmacology https://youtu.be/aI4yub5GMF0 Autonomic nervous system | nervous system pharmacology | ANS- sympathetic & parasympathetic https://youtu.be/8zkEknWiEj0 Support us on: Facebook https://web.facebook.com/MK-MediGuide... ==================================================================== #MKMediguide #mediguide #cholinomimetics #CholinergicAgonists #CholinerReceptorsAgonists #acetylcholineReceptorsAgonists #pharmacology #Parasympathomimetics #MucarinicAgonists #NicotinicAgonists