Cytokine storm | Cytokine release syndrome | pathophysiology mechanism of CS

In this lecture, we’ll talk over what is known so far about cytokine storm syndrome linked with SARS-CoV-2 infection, including cytokines that are chiefly involved. This lecture mainly enlightens about the immunological mechanism of immune system hyperactivation, which releases a lot of cytokines, that act as cell signaling molecules in the immune system, particularly during COVID-19 proinflammatory cytokines are released in high proportion leading to CYTOKINE STORM. This is a very serious complication that is emerging in a subset of patients which is the leading cause of death in mostly COVID-19 ill patients. Once the cytokine storm occurs, it can cause pneumonia, ARDS and multi-organ failure, MOF occur due to the blood vessel wall become thin and cause the release of blood plasma leads to the blood clot in the blood vessel and that leads to the prevented blood supply to the vital organs of our body like lungs, kidney, and liver.

The following TOPICS are COVERED in this lecture
cytokine storm or cytokine release syndrome or hypercytokinemia in COVID-19
Mechanism of the pathophysiology of cytokine storm
in normal mean asymptomatic and mild patients
in severe patients
cytokines majorly involved in cytokine storm
Interleukin-6 (IL-6), Tumor necrosis factor-alpha (TNF-a), Interleukin-1B, TGF-B, G-CSF, GM-CSF, Interleukin-17 (IL-17), and other important cytokines
Diagnostic features of cytokine storm

Links:
Also watch:

SARS-CoV-2 || pathophysiology and symptoms of COVID-19
https://youtu.be/B2pRcQ3xUa4
Dexamethasone for COVID-19 | Mechanism of action
https://youtu.be/PIr23fNCOE8
How drugs act
https://www.youtube.com/watch?v=iZLAMgHIH2k
Receptor and its types
https://www.youtube.com/watch?v=-xS5rBJwAKM

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